Review Paper on TPIAT:
Total pancreatectomy and islet autotransplantion for chronic and recurrent acute pancreatitis
Kendall R. McEachron, Melena D. Bellin
Curr Opin Gastroenterol. 2018 Sep; 34(5): 367–373. PMCID: PMC9623823
Selected Other Research Publications on TPIAT from the University of Minnesota:
Peri-Transplant Inflammation and Long-Term Diabetes Outcomes Were Not Impacted by Either Etanercept or Alpha-1-Antitrypsin Treatment in Islet Autotransplant Recipients
Abdel-Karim TR, Hodges JS, Herold KC, Pruett TL, Ramanathan KV, Hering BJ, Dunn TB, Kirchner VA, Beilman GJ, Bellin MD. Peri-Transplant Inflammation and Long-Term Diabetes Outcomes Were Not Impacted by Either Etanercept or Alpha-1-Antitrypsin Treatment in Islet Autotransplant Recipients. Transpl Int. 2024 Jan 31;37:12320. PMID: 38357216; PMCID:PMC10864605.
Diabetes related genetics and outcomes after total pancreatectomy with islet autotransplantation.
Triolo TM, Eaton AA, Chen WM, Witkowski P, Abu-El-Haija M, Ahmad SA, Mokshagundam SP, Wijkstrom M, Naziruddin B, Singh VK, Posselt A, Nathan JD, Morgan K, Lara LF, Gardner TB, Onengut-Gumuscu S, Steck AK, Bellin MD. J Clin Endocrinol Metab. 2026 Sep 11:dgag355. doi: 10.1210/clinem/dgag355. Online ahead of print. PMID: 42722448
Rates of hospitalization pre- and post-total pancreatectomy with islet autotransplantation for patients with pancreatitis.
Jagadesh N, Eaton A, Ghai MB, Trikudanathan G, Robinson KD, Singh VK, Nathan JD, Chinnakotla S, Abu-El-Haija M, Ahmad SA, Gardner TB, Lara LF, Morgan K, Mokshagundam SP, Naziruddin B, Posselt A, Wijkstrom M, Witkowski P, Beilman G, Bellin MD. Surg Endosc. 2026 Aug 26. doi: 10.1007/s00464-026-13228-z. Online ahead of print. PMID: 42649421
Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic pancreatitis
Osorio-Vasquez V, Zhu J, Lumibao JC, Lande K, Peck KL, Stamp MK, Okhovat SR, Song H, Ogawa S, Kubota CS, Pantazopoulou V, Curtis K, Kuo K, Dai Y, Rock A, Bottomley CR, Thomas EJ, Hsu J, Herrera Morales A, Fowler A, McGriff T, Evensen KG, Williams AE, Larsen S, Abdulla M, Greer P, Gibson J, Downes M, Evans RM, Lowy AM, Whitcomb DC, Zou J, Molinolo A, Oh TG, White RR, Bellin M, Tiriac H, Engle DD. Cell Stem Cell. 2026 Aug 6;33(8):1270-1288.e7. doi: 10.1016/j.stem.2026.06.002. Epub 2026 Jun 30. PMID: 42379165 Free PMC article.
Poor Glycemic Status Is Associated With Diabetes Distress After Total Pancreatectomy With Islet Autotransplantation.
Ishola FA, Eaton A, Kim S, Basina M, Beilman G, Bellin M. Clin Transplant. 2026 May;40(5):e70573. doi: 10.1111/ctr.70573. PMID: 42165339
Hypoglycemia Occurrence and Risk Factors in Insulin Independent Patients After Total Pancreatectomy With Islet Autotransplantation.
Hassaan A, Eaton A, Jagadesh N, Trikudanathan G, Freeman M, Downs E, Chinnakotla S, Martin D, Ramanathan K, Beilman GJ, Bellin MD. Clin Transplant. 2026 May;40(5):e70549. doi: 10.1111/ctr.70549. PMID: 42053924 Free PMC article.
Islet Autotransplant Recipients Have Elevated Proinsulin-to-C-Peptide Ratios Supporting Metabolic Stress as a Cause of Islet Attrition.
Ali E, Eaton A, Rickels MR, Evans-Molina C, Ramanathan K, Martin D, Trikudanathan G, Downs E, Beilman GJ, Bellin MD. Diabetes. 2026 Jul 1;75(7):1210-1220. doi: 10.2337/db26-0011. PMID: 42048053 Free PMC article.
SPINK1 p.Asn34Ser Haplotype Reduces Pancreatic Trypsin Inhibitor Messenger RNA in Chronic Pancreatitis Patients Undergoing Total Pancreatectomy With Islet Autotransplantation.
Berke G, Abu-El-Haija M, Morgan K, Singh VK, Bellin MD, Sahin-Tóth M. Gastroenterology. 2026 Aug;171(2):370-372. doi: 10.1053/j.gastro.2026.02.046. Epub 2026 Apr 1. PMID: 41932452 No abstract available.
Gastrointestinal Symptom Burden After Total Pancreatectomy With Islet Autotransplantation: A Prospective Observational Cohort Study.
Hirsch W, Downs EM, Freeman M, Beilman G, Martin D, Trikudanathan G, Ramanathan K, Vaughn BP, Bellin MD. Pancreas. 2026 May-Jun 01;55(5):e511-e517. doi: 10.1097/MPA.0000000000002587. Epub 2025 Oct 30. PMID: 41172147
Predictors of Diabetes Outcomes at 1 Year After Islet Autotransplantation: Data From a Multicenter Cohort Study.
Witkowski P, Eaton A, Porter S, Abu-El-Haija M, Ahmad SA, Mokshagundam SP, Wijkstrom M, Naziruddin B, Trikudanathan G, Singh VK, Schwarzenberg SJ, Pruett TL, Posselt A, Nathan JD, Morgan K, Lara LF, Gardner TB, Freeman M, Faghih M, Downs EM, Chinnakotla S, Balamurugan AN, Adams D, Beilman GJ, Bellin MD. Diabetes Care. 2025 Sep 1;48(9):1493-1501. doi: 10.2337/dc25-0620. PMID: 40632944 Free PMC article.
Total Pancreatectomy With Islet Autotransplantation for Chronic Pancreatitis.
Trikudanathan G, Eaton A, Freeman ML, Singh VK, Schwarzenberg SJ, Nathan JD, Beilman GJ, Abu-El-Haija M, Adams D, Ahmad SA, Chinnakotla S, Downs EM, Faghih M, Gardner TB, Lara LF, Morgan K, Mokshagundam SP, Naziruddin B, Posselt A, Pruett TL, Wijkstrom M, Witkowski P, Bellin MD. Gastroenterology. 2025 Dec;169(7):1499-1509. doi: 10.1053/j.gastro.2025.04.040. Epub 2025 Jun 14. PMID: 40523532
Defining Targets for Continuous Glucose Monitoring After Total Pancreatectomy With Islet Autotransplantation.
Somani Z, Hodges JS, Chinnakotla S, Martin D, Ramanathan K, Beilman GJ, Bellin MD. Clin Transplant. 2025 Jun;39(6):e70202. doi: 10.1111/ctr.70202. PMID: 40454809 Free PMC article.
Abdominal Pain Following Total Pancreatectomy With Islet Autotransplantation.
Harrison J, Shaaban MA, Scheidecker E, Ramanathan K, Freeman M, Trikudanathan G, Martin D, Chinnakotla S, Downs EM, Schwarzenberg SJ, Bellin MD, Beilman G. Pancreas. 2025 Sep 1;54(8):e719-e727. doi: 10.1097/MPA.0000000000002510. PMID: 40333060 Review.
Long-Term Islet Graft Functional Assessment in More than 500 Patients Undergoing Total Pancreatectomy with Intraportal Islet Autotransplantation.
Bellin MD, Eaton A, Ramanathan K, Beilman G, Downs E, Schwarzenberg SJ, Trikudanathan G, Freeman M, Sutherland D, Chinnakotla S. J Am Coll Surg. 2025 Apr 1;240(4):405-413. doi: 10.1097/XCS.0000000000001294. Epub 2025 Mar 17. PMID: 39840847
Peri-Transplant Inflammation and Long-Term Diabetes Outcomes Were Not Impacted by Either Etanercept or Alpha-1-Antitrypsin Treatment in Islet Autotransplant Recipients
Abdel-Karim TR, Hodges JS, Herold KC, Pruett TL, Ramanathan KV, Hering BJ, Dunn TB, Kirchner VA, Beilman GJ, Bellin MD. Peri-Transplant Inflammation and Long-Term Diabetes Outcomes Were Not Impacted by Either Etanercept or Alpha-1-Antitrypsin Treatment in Islet Autotransplant Recipients. Transpl Int. 2024 Jan 31;37:12320. PMID: 38357216; PMCID:PMC10864605.
How Durable Is Total Pancreatectomy and Intraportal Islet Cell Transplantation for Treatment of Chronic Pancreatitis?
Melena D Bellin, Gregory J Beilman, David ER Sutherland, Hawa Ali, Arzu Petersen, Steven Mongin, Varvara Kirchner, Sarah J Schwarzenberg, Guru Trikudanathan, Martin L Freeman, Timothy L Pruett, Srinath Chinnakotla
J Am Coll Surg. Author manuscript; available in PMC 2021 Nov 10. J Am Coll Surg. 2019 Apr; 228(4): 329–339. PMCID: PMC8579321.
Early Metabolic Measures Predict Long-term Insulin Independence in Recipients of Total Pancreatectomy and Islet Autotransplantation
Yoshihide Nanno, James S. Hodges, Martin L. Freeman, Guru Trikudanathan, Sarah J. Schwarzenberg, Elissa M. Downs, Karthik Ramanathan, Timothy L. Pruett, Gregory J. Beilman, Srinath Chinnakotla, Bernhard J. Hering, Melena D. Bellin
Transplant Direct. 2024 Jan; 10(1): e1561. Published online 2023 Dec 12. PMCID: PMC10715795.
A randomized controlled pilot trial of etanercept and alpha-1 antitrypsin to improve autologous islet engraftment
Tasneem R. Abdel-karim, James S. Hodges, Timothy L. Pruett, Karthik V. Ramanathan, Bernhard J. Hering, Ty B. Dunn, Varvara A. Kirchner, Gregory J. Beilman, Melena D. Bellin
Pancreatology. 2023 Jan; 23(1): 57–64. Published online 2022 Nov 24. PMCID: PMC9839597.
Decreased Intestinal Microbiota Diversity is Associated With Increased Gastrointestinal Symptoms in Patients With Chronic Pancreatitis
Kendall R. McEachron, Harika Nalluri, Gregory J. Beilman, Varvara A. Kirchner, Timothy L. Pruett, Martin L. Freeman, Guru Trikudanathan, Christopher Staley, Melena D. Bellin
Pancreas. 2022 Jul 1; 51(6): 649–656. Published online 2022 Sep 13. PMCID: PMC9547966.
Surgical approach and short-term outcomes in adults and children undergoing total pancreatectomy with islet autotransplantation: A report from the Prospective Observational Study of TPIAT
Jaimie D. Nathan, Yi Yang, Anne Eaton, Piotr Witkowski, Martin Wijkstrom, Matthew Walsh, Guru Trikudanathan, Vikesh K. Singh, Sarah J. Schwarzenberg, Timothy L. Pruett, Andrew Posselt, Bashoo Naziruddin, Sri Prakash Mokshagundam, Katherine Morgan, Luis F. Lara, Varvara Kirchner, Jin He, Timothy B. Gardner, Martin L. Freeman, Kate Ellery, Darwin L. Conwell, Srinath Chinnakotla, Gregory J. Beilman, Syed Ahmad, Maisam Abu-El-Haija, James S. Hodges, Melena D. Bellin
Pancreatology. 2022 Jan; 22(1): 1–8. Published online 2021 Sep 29. PMCID: PMC8748311.
Reduced Bone Mineral Density in the First Year After Total Pancreatectomy with Islet Autotransplantation (TPIAT)
Jillian K. Wothe, Robert Aidoo, Kendall R. McEachron, Tasma Harindhanavudhi, Guru Trikudanathan, Martin L. Freeman, Varvara Kirchner, Timothy L. Pruett, Gregory J. Beilman, James S. Hodges, Melena D. Bellin
Pancreatology. 2021 Dec; 21(8): 1491–1497. Published online 2021 Sep 4. PMCID: PMC8629939.
Type 1 diabetes mellitus in patients with recurrent acute and chronic pancreatitis: a case series
Harmeet K. Kharoud, Tetyana Mettler, Martin L. Freeman, Guru Trikudanathan, Gregory J. Beilman, Srinath Chinnakotla, Elissa Downs, Sarah J. Schwarzenberg, Melena D. Bellin
Pancreatology. 2021 Jan; 21(1): 95–97. Published online 2020 Dec 6. doi: 10.1016/j.pan.2020.12.006 PMCID: PMC7856006.
Preoperative ERCP has no impact on islet cell yield following total pancreatectomy and islet transplantation (TPIAT): Results from the Prospective Observational Study of TPIAT (POST) cohort
Guru Trikudanathan, B. Joseph Elmunzer, Yi Yang, Maisam Abu-El-Haija, David Adams, Syed Ahmad, Appakalai N. Balamurugan, Gregory J. Beilman, Srinath Chinnakotla, Darwin L. Conwell, Martin L. Freeman, Timothy B. Gardner, Betul Hatipoglu, James S. Hodges, Varvara Kirchner, Luis F. Lara, Leslie Long-Simpson, Rebecca Mitchell, Katherine Morgan, Jaimie D. Nathan, Bashoo Naziruddin, Andrew Posselt, Timothy L. Pruett, Sarah J. Scwarzenberg, Vikesh K. Singh, Kerrington Smith, Martin Wijkstrom, Piotr Witkowski, Melena D. Bellin
Pancreatology. 2021 Jan; 21(1): 275–281. Published online 2020 Nov 24. doi: 10.1016/j.pan.2020.11.008 PMCID: PMC7924984.
Alterations in Enteroendocrine Hormones After Total Pancreatectomy With Islet Autotransplantation
Pancreas. Author manuscript; available in PMC 2021 Jul 1. PMCID: PMC7321866
Utility of arginine stimulation testing in preoperative assessment of children undergoing total pancreatectomy with islet autotransplantation
Kendall R. McEachron, Mariya E. Skube, Yi Yang, James S. Hodges, Joshua Wilhelm, Gregory Beilman, Srinath Chinnakotla, Sarah J. Schwarzenberg, Melena D. Bellin
Clin Transplant. Author manuscript; available in PMC 2020 Aug 1.
Published in final edited form as: Clin Transplant. 2019 Aug; 33(8): e13647. Published online 2019 Jul 4. doi: 10.1111/ctr.13647 PMCID: PMC7041967.
Islet Graft Function Is Preserved After Pregnancy in Patients With Previous Total Pancreatectomy With Islet Autotransplant
Mariya E. Skube, Pamela D. Mills, James S. Hodges, Greg J. Beilman, Melena D. Bellin
Pancreas. Author manuscript; available in PMC 2019 Jul 3.
Published in final edited form as: Pancreas. 2018 Oct; 47(9): e64–e65. doi: 10.1097/MPA.0000000000001129 PMCID: PMC6609149.
Psychiatric Comorbidities in Patients Undergoing Total Pancreatectomy With Islet Cell Autotransplantation and Associated Mortality
Kendall R. McEachron, Mary Melton, Gregory J. Beilman, Melena D. Bellin
Pancreas. Author manuscript; available in PMC 2022 Nov 10.
Published in final edited form as: Pancreas. 2018 Apr; 47(4): e16–e18. doi: 10.1097/MPA.0000000000001010 PMCID: PMC9648619.
Accuracy of Continuous Glucose Monitoring in Patients After Total Pancreatectomy with Islet Autotransplantation
Gregory P. Forlenza, Brandon M. Nathan, Antoinette Moran, Ty B. Dunn, Gregory J. Beilman, Timothy L. Pruett, Boris P. Kovatchev, Melena D. Bellin
Diabetes Technol Ther. 2016 Aug 1; 18(8): 455–463. Published online 2016 Aug 1. doi: 10.1089/dia.2015.0405 PMCID: PMC4991614.
Preoperative Computerized Tomography and Magnetic Resonance Imaging of the Pancreas Predicts Pancreatic Mass and Functional Outcomes After Total Pancreatectomy and Islet Autotransplant
Michael C. Young, Jake R. Theis, James S. Hodges, Ty B. Dunn, Timothy L. Pruett, Srinath Chinnakotla, Sidney P. Walker, Martin L. Freeman, Guru Trikudanathan, Mustafa Arain, R. Paul Robertson, Joshua J. Wilhelm, Sarah J. Schwarzenberg, Barbara Bland, Gregory J. Beilman, Melena D. Bellin
Pancreas. Author manuscript; available in PMC 2017 Aug 1.
Published in final edited form as: Pancreas. 2016 Aug; 45(7): 961–966. doi: 10.1097/MPA.0000000000000591 PMCID: PMC4936953.
Metastatic Pancreatic Adenocarcinoma After Total Pancreatectomy Islet Autotransplantation for Chronic Pancreatitis
S. Muratore, X. Zeng, M. Korc, S. McElyea, J. Wilhelm, M. Bellin, G. Beilman
Am J Transplant. Author manuscript; available in PMC 2017 Sep 1.
Published in final edited form as: Am J Transplant. 2016 Sep; 16(9): 2747–2752. Published online 2016 Jun 27. doi: 10.1111/ajt.13851 PMCID: PMC5007168.
Pancreatogenic Diabetes in Children With Recurrent Acute and Chronic Pancreatitis: Risks, Screening, and Treatment (Mini-Review)
Melena D. Bellin
Front Pediatr. 2022; 10: 884668. Published online 2022 Apr 26. PMCID: PMC9086714.
The above articles are externally sourced and were published prior to current ADA guidelines. If you would like accessible versions of any of the above documents, please email [email protected].